By Health Publica Icon Health Publications
It is a 3-in-1 reference booklet. It provides an entire clinical dictionary overlaying thousands of phrases and expressions when it comes to antibiotics. It additionally supplies large lists of bibliographic citations. ultimately, it offers info to clients on tips on how to replace their wisdom utilizing quite a few web assets. The e-book is designed for physicians, clinical scholars getting ready for Board examinations, clinical researchers, and sufferers who are looking to familiarize yourself with learn devoted to antibiotics. in the event that your time is efficacious, this booklet is for you. First, you won't waste time looking the net whereas lacking loads of suitable details. moment, the publication additionally saves you time indexing and defining entries. ultimately, you won't waste money and time printing thousands of web content.
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Extra info for Antibiotics - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References
Based on these observations and the known features of bacterial antibiotic efflux systems, we hypothesize that CmeDEF in conjunction with CmeABC plays an important role in extruding various agents, and the modulated expression of the efflux pumps by regulatory proteins contributes significantly to the intrinsic and acquired resistance of Campylobacter to multiple antimicrobials. To test our hypothesis, we plan to i) determine the role of CmeDEF and its interplay with CmeABC in mediating Campylobacter resistance to multiple drugs and ii) to identify and characterize the transcriptional repressors that modulate the expression of the antibiotic efflux systems.
The multiple experimental approaches outlined in this proposal should lead to a better understanding of the mechanism(s) involved in development of biofilm-specific antibiotic resistance, and potentially to new therapeutic strategies for modulating these properties. Specific Aim I. Studies of known genes in biofilm-specific antibiotic resistance. Specific Aim II. Determine the role of a glucan synthetase enzyme in the development of biofilm-specific antibiotic resistance. Specific Aim III. Studies of the role of a putative new efflux pump in biofilm-specific antibiotic resistance.
The outcome of this 2-year development program will be a drug candidate ready for Phase I clinical evaluation in humans. S. Sepsis caused by Gram-negative bacteria results from adverse host immune response to the Lipid A (LA) portion of endotoxin. Compounds with high affinity for LA, including polymyxin B (PMB) and derivatives, are capable of detoxifying LA nd protection a host against sepsis. By binding LA, these compounds also sensitize Gram-negative bacteria to hydrophobic antibiotics. However, therapeutic use of PMB is limited due to its toxicity.
Antibiotics - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by Health Publica Icon Health Publications