By Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh
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Extra info for Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology)
GR Waller, MS Feather, pp. 507–19. Washington, DC: Amer. Chem. Soc. Grivas S, Nyhammar T, Olsson K, J¨agerstad M. 1985. Formation of a new mutagenic DiMeIQx compound in a model system by heating creatinine, alanine and fructose. Mutat. Res. 151:177–83 Nyhammar T, Grivas S, Olsson K, J¨agerstad M. 1986. Formation of 4,8- 20. 21. 22. 23. 24. 25. 26. 27. 28. DiMeIQx from the model system fructose, alanine and creatinine. Comparison with the isomeric 5,8-DiMeIQx. Mutat. Res. 174:5–9 Eisenbrand G, Tang W.
CONCLUSIONS AND FURTHER QUESTIONS Human cancer risk associated with HAAs depends on the level of dietary exposure in the population, the biologically effective doses arising from those exposures within relevant target tissues, and the relationship between these effective doses and predicted increased cancer risk (159). Industrial exposure to known carcinogenic Figure 6 Other drugs known to undergo Nhydroxylation. sgm LaTeX2e(2002/01/18) P1: GCE Annu. Rev. Pharmacol. Toxicol. 45:27-49. org by Universitaet Heidelberg on 10/01/05.
Chem. Hoppe-Seyler 368:895–902 Eyer P. 1988. Detoxication of Noxygenated arylamines in erythrocytes. An overview. Xenobiotica 18:1327–33 Mandell GL, Sande MA. 1985. Antimicrobial agents: sulfonamides, trimethoprim-sulfamethoxazole and agents for urinary tract infections. In The Pharmacological Basis of Therapeutics, ed. AG Gillam, LS Goodman, TW Rall, R Marud, pp. 1095–114. New York: Macmillan Cribb AE, Spielberg SP, Griffin GP. 1995. N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes.
Annual Review of Pharmacology and Toxicology Volume 45, 2005 (Annual Review of Pharmacology and Toxicology) by Arthur K. Cho, Terrence F. Blaschke, Paul A. Insel, Horace H. Loh