By Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)
Androgens and androgen receptors (AR) play severe roles within the improvement and development of prostate melanoma, the main often clinically determined melanoma and moment top explanation for melanoma dying in US men. AR is an androgen-dependent DNA-binding transcription issue that regulates the expression of androgen-responsive genes. identity and characterization of androgen-responsive genes supply insights into the mobile mechanisms of androgen motion and will result in new ways in analysis, diagnosis, prevention and/or remedy of prostate melanoma. This quantity offers severe details from good revered specialists within the box. many of the interesting subject matters comprise the recent realizing of mechanisms underlining the law of androgen-responsive gene expression, and features of varied androgen-responsive genes in organic procedures crucial in carcinogenesis together with telephone development, angiogenesis, and epithelial-to-mesenchyme transition (EMT). different vital elements addressed are the present and capability sanatorium functions of information on androgen-responsive gene law and serve as. This e-book is meant for researchers, scientists, college, and complicated graduate scholars with an curiosity in androgen motion and prostate cancer.
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Additional info for Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications
Despite strong indications, this still needs to be proven in structural analyses. – Can we exploit the allosteric signals between the DBD and the other domains and translate them in one or more therapeutic targets? – What is the exact role of selective AREs in prostate cancer, and in the control of the cell cycle in the primary tumor as well as in the metastases, be it hormone sensitive or castration resistant? 02 and G. 11N. C. is holder of a Doctoral Fellowship of the “Agentschap voor Innovatie door Wetenschap en Technologie”.
J Cell Biochem 35:285–292 29. Roche PJ, Hoare SA, Parker MG (1992) A consensus DNA-binding site for the androgen receptor. Mol Endocrinol 6:2229–2235 30. Claessens F, Alen P, Devos A et al (1996) The androgen-specific probasin response element 2 interacts differentially with androgen and glucocorticoid receptors. J Biol Chem 271:19013–19016 31. Verrijdt G, Schoenmakers E, Haelens A et al (2000) Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor.
To our surprise, when we used deletion constructors that inserted shorter DNA fragments of these nARPEs into pGL3-4xARE-E4-luc between 4xARE and E4, we could not figure out a short sequence that responses for negative regulation of AR-driven transcriptional activity. Instead, we observed gradual decrease in the activity of nARPEs when truncated from 3¢ or 5¢ ends. These observations suggest that these nARPEs contain multiple cis-elements that function synergistically. When put four nARPEs in their natural or reverse orientation, all of them showed dramatic inhibition effect on AR-driven transcriptional activities.
Androgen-Responsive Genes in Prostate Cancer: Regulation, Function and Clinical Applications by Irina U. Agoulnik, Nancy L. Weigel (auth.), Zhou Wang (eds.)