Download e-book for iPad: Adverse Drug Reactions by Michael Holt, Cynthia Ju (auth.), Jack Uetrecht (eds.)

By Michael Holt, Cynthia Ju (auth.), Jack Uetrecht (eds.)

ISBN-10: 3642006620

ISBN-13: 9783642006623

This e-book offers the present country of data of uncomplicated mechanisms of inauspicious drug reactions (ADRs). the main target is on idiosyncratic drug reactions simply because they're the main tricky to house. It starts off with a basic description of the key objectives for ADRs by way of an outline of what are almost immediately believed to be mediators and biochemical pathways taken with idiosyncratic drug reactions. there's additionally an outline of a number of examples of ADRs that serve to demonstrate particular facets of ADR mechanisms. finally the publication indicates that finally larger equipment are had to expect which drug applicants tend to reason ADRs and which sufferers are at elevated chance. yet at the moment study appears faraway from this goal.

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6 Flare Up Reactions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 5 Conclusion . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 52 Abstract Immune reactions to drugs can cause a variety of diseases involving the skin, liver, kidney, lungs, and other organs.

52 Abstract Immune reactions to drugs can cause a variety of diseases involving the skin, liver, kidney, lungs, and other organs. Beside immediate, IgE-mediated reactions of varying degrees (urticaria to anaphylactic shock), many drug hypersensitivity reactions appear delayed, namely hours to days after starting drug treatment, showing a variety of clinical manifestations from solely skin involvement to fulminant systemic diseases which may be fatal. Immunohistochemical and functional studies of drug-specific T cells in patients with delayed reactions confirmed a predominant role for T cells in the onset and maintenance of immunemediated delayed drug hypersensitivity reactions (type IV reactions).

2 T Cell-Mediated Drug Hypersensitivity Restimulation of Primed T Cells by Drug-Carrier Complexes (Hapten Model) Upon reexposure to a drug acting as hapten or becoming a hapten after metabolism, the hapten-carrier-compounds are formed again and can be recognized by primed effector T cells. Recognition and the ensuing inflammation will take place in the involved tissue or in the corresponding draining lymph nodes. The tissue can be the skin, but also other organs where the drug or hapten-carrier compounds are present (Fig.

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Adverse Drug Reactions by Michael Holt, Cynthia Ju (auth.), Jack Uetrecht (eds.)

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