By Mariusz Z. Ratajczak
This well timed quantity explores a number of innovations for tissue and organ regeneration utilizing stem cells remoted from grownup tissues. It discusses replacement factors of stem mobile plasticity in addition to present scientific effects with grownup stem phone treatments. It examines the presence of strength pluripotent stem cells in grownup tissues, paracrine results of stem phone remedies, and involvement of exosomes and microparticles into saw phenomena. Fifteen chapters, all written through famous leaders in their fields, specialise in a number of themes together with wire blood and hematopoietic stem cells, pores and skin and tissue organ regeneration, very small embryonic-like stem cells, and telephone cures in cardiology, neonatology, and neurology. Edited via Dr. Mariusz Ratajczak, an the world over recognized expert in grownup stem cellphone biology, Adult Stem mobilephone treatments: possible choices to Plasticity is a crucial addition to the Stem mobilephone Biology and Regenerative Medicine series.
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Extra resources for Adult Stem Cell Therapies: Alternatives to Plasticity
Stem Cells Dev 21:670–674 49. Parte S, Bhartiya D, Telang J, Daithankar V, Salvi V, Zaveri K et al (2011) Detection, characterization, and spontaneous differentiation in vitro of very small embryonic-like putative stem cells in adult mammalian ovary. Stem Cells Dev 20:1451–1464 50. Kucia M, Shin DM, Liu R, Ratajczak J, Bryndza E, Masternak MM et al (2011) Reduced number of VSELs in the bone marrow of growth hormone transgenic mice indicates that chronically elevated Igf1 level accelerates age-dependent exhaustion of pluripotent stem cell pool: a novel view on aging.
Nat Protoc 8:1391–1415 84. Wakao S, Kitada M, Kuroda Y, Shigemoto T, Matsuse D, Akashi H et al (2011) Multilineagedifferentiating stress-enduring (Muse) cells are a primary source of induced pluripotent stem cells in human fibroblasts. Proc Natl Acad Sci U S A 108:9875–9880 85. Le Blanc K, Pittenger M (2005) Mesenchymal stem cells: progress toward promise. Cytotherapy 7:36–45 86. Vacanti MP, Roy A, Cortiella J, Bonassar L, Vacanti CA (2001) Identification and initial characterization of spore-like cells in adult mammals.
PSCs must first be purified in therapeutically significant quantities from adult tissues and efficiently expanded ex vivo before they can be successfully employed in the clinic 22 M. Kucia et al. 2 Presence of Potential Pluripotent Stem Cells in Cell Preparations Derived from Adult Tissues From a developmental point of view, an important question is why should PSCs may reside in adult organs? For many years, it has been accepted that adult tissues contain only tissue-committed stem cells (TCSCs), such as epidermal stem cells, hematopoietic stem cells, or skeletal muscle stem cells, that have a limited potential for differentiation.
Adult Stem Cell Therapies: Alternatives to Plasticity by Mariusz Z. Ratajczak