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1944), which is presented in Table 4. However, though the regulations prescribe these different test methods, most laboratories actually perform some modified methods. Here, two modifications (one for irritation and the other for corrosion) which reflect prior laboratory experience are recommended. PRIMARY DERMAL IRRITATION TEST [FIGS. 5, 5A (SEE COLOR PLATES), AND 6] A. Rabbit screening procedure 1. A group of at least 8-12 New Zealand White rabbits are screened for the study. 2. All rabbits selected for the study must be in good health; any rabbit exhibiting snuffles, hair loss, loose stools, or apparent weight loss is rejected and replaced.

Pharmacol. 1, 19-58. Cramner, C. , Ford, R. , and Hall, R. L. (1978). Estimation of toxic hazardmA decision tree approach. Fd. Cosmet. Toxicol. 16, 255-276. Gad, S. , and Weil, C. S. (1988). Statistics and Experimental Design for Toxicologists, 2nd ed. Telford Press, Caldwell, NJ. J. (1981). Scientific Considerations in Monitoring and Evaluating Toxicological Research. Hemisphere, New York. Larson, D. , King, T. , Nelson, R. , and Gad, S. C. (1995). Information sources: Building and maintaining data files.

M. ), Vol. 5, pp. 115-128. Liebert, New York. DeLeo, V. , Harber, L. , Kong, B. , and Salva, S. D. (1987). Surfactantinduced cutaneous primary irritancy: An in vitro model. In Alternative Methods in Toxicology (A. M. ), Vol. 5. , 129-138. Liebert, New York. , and Bagley, D. (1988). Surfactant-induced cutaneous primary irritancy: An in vitro model-assay system development. In Progress in in Vitro Toxicology (A. M. ), pp. 39-43. Liebert, New York. Department of Transportation Code of Federal Regulations (1992).

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Acute toxicology


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