Download e-book for kindle: A Pharmacology Primer: Theory, Applications, and Methods by Terry Kenakin

By Terry Kenakin

ISBN-10: 0123705991

ISBN-13: 9780123705990

The second one variation will proceed this practice of higher getting ready researchers within the fundamentals of pharmacology. additionally, new human curiosity fabric together with ancient proof in pharmacology may be further. a brand new part on therapeutics can assist readers determine with illnesses and drugs.

*Over 30 new figures and tables
*More human curiosity details to supply readers with old proof on pharmacology research
*New part on therapeutics to aid establish diseaes and drug treatments
*New part on new organic ideas suitable to pharmacological study (i.e., platforms biology)
*New examine sections prepared with ASPET and different foreign pharmacology organizations
*New insurance of pharmacokinetics and drug disposition

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Additional resources for A Pharmacology Primer: Theory, Applications, and Methods (2nd Edition)

Example text

Trends Pharmacol. Sci. 18:456–464. 11. , Lansdell, S. , Wilson, H. , and Martin, G. R. (1996). Characterization of a 5-HT1B receptor on CHO cells: Functional responses in the absence of radioligand binding. Br. J. Pharmacol. 117:1119–1126. 12. , and Li, C. H. (1980). b-endorphin: Radioreceptor binding assay. Int. J. Pept. Protein Res. 16:66–69. 3 Drug-Receptor Theory What is it that breathes fire into the equations and makes a universe for them to describe? — STEPHEN W. HAWKING An equation is something for eternity.

4:153–159. 8. Burgen, A. S. , and Spero, L. (1968). The action of acetylcholine and other drugs on the efflux of potassium and rubidium from smooth muscle of the guinea-pig intestine. Br. J. , 34:99–115. 9. Paton, W. D. M. (1986). On becoming a pharmacologist. Ann. Rev. Pharmacol. and Toxicol. 26:1–22. 10. Kenakin, T. P. (1997). Differences between natural and recombinant G-protein coupled receptor systems with varying receptor/G-protein stoichiometry. Trends Pharmacol. Sci. 18:456–464. 11. , Lansdell, S.

These are described separately as a background to discussion of drug-receptor activity and as context for the description of the quantitative tools and methods used in receptor pharmacology to quantify drug effect. 3 The Use of Mathematical Models in Pharmacology Mathematical models are the link between what is observed experimentally and what is thought to occur at the molecular level. , a nuclear magnetic resonance spectrum directly reflects the interaction of hydrogen atoms on a molecule). In pharmacology the observations are much more indirect, leaving a much wider gap between the physical chemistry involved in drugreceptor interaction and what the cell does in response to those interactions (through the ‘‘cellular veil’’).

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A Pharmacology Primer: Theory, Applications, and Methods (2nd Edition) by Terry Kenakin


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