By John R. Fozard (auth.), Pier Andrea Borea (eds.)
This publication "A3 Adenosine Receptors from telephone Biology to Pharmacology and Therapeutics " records the current kingdom of data of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that functionality in body structure and intracellular signaling and are fascinated with inflammatory responses and mediating telephone proliferation and telephone loss of life.
The A3 receptor is more and more being famous for its organic roles in the course of the physique, and lots of A3 receptor ligands have confirmed priceless in elucidating peripheral and critical pathologies. This ebook covers quite a lot of info together with information from reports of theoretical, molecular and mobile pharmacology, sign transduction, integrative body structure, new drug discoveries and scientific purposes. The e-book contains sections on:
- A3 Adenosine Receptor sign transduction
- Adenosine Receptor medicinal chemistry
- Effects and healing purposes of Adenosine Receptors on tissues and organs
- Adenosine Receptors and inflammatory and auto-immune diseases
- Adenosine Receptors and cancer
The chapters during this ebook hide either basic technology and correct functions and supply an authoritative account of the present prestige of the sector. "A3 Adenosine Receptors from mobile Biology to Pharmacology and Therapeutics" is an up to the moment and scientifically very good resource of data, appealing to uncomplicated and medical scientists alike.
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Additional resources for A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics
Such a method has proved to be successful in many cases and has been applied to the study of several GPCR membrane receptors such as b-adrenoceptor, serotonin 5HT1, µ, d, k opioid and nociceptin, dopamine D2, histamine H3 and cholecystokinin CCK2 receptors (Weiland et al. 1979; Dalpiaz et al. 1996; Borea et al. 1988; Varani et al. 1998; Duarte et al. 1988; Harper and Black 2007; Harper et al. 2008). Similarly also A1, A2A, A2B and A3 adenosine receptors have been thermodynamically studied (Borea et al.
J Biol Chem 268:16887–16890 Reeves JJ, Harris CA, Hayes BP, Butchers PR, Sheehan MJ (2000) Studies on the effects of adenosine A3 receptor stimulation on human eosinophils isolated from non-asthmatic or asthmatic donors. Inflamm Res 49:666–672 Renzi PM, Olivenstein R, Martin JG (1993) Inflammatory cell populations in the airways and parenchyma after antigen challenge in the rat. Am Rev Resp Dis 147:967–974 Renzi PM, Al-Assaad AS, Yang JP, Yasruel Z, Hamid Q (1996) Cytokine expression in the presence or absence of late airway responses after allergen challenge of sensitised animals.
Mol Pharmacol 63:342–350 Fozard JR, Carruthers AM (1993a) The cardiovascular effects of selective adenosine A1 and A2 receptor agonists in the pithed rat: no role for glibenclamide-sensitive potassium channels. Naunyn Schmiedebergs Arch Pharmacol 347:192–196 Fozard JR, Carruthers AM (1993b) Adenosine A3 receptors mediate hypotension in the angiotensin II-supported circulation of the pithed rat. Br J Pharmacol 109:3–5 Fozard JR, Hannon JP (1994) BW-A522 blocks adenosine A3 receptor mediated hypotensive responses in the rat.
A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics by John R. Fozard (auth.), Pier Andrea Borea (eds.)